朱改只
北京脑重大疾病研究院 博士后
联系电话：18600335944
邮箱：zhugaizhi@outlook.com
教育经历
2024-至今 首都医科大学 免疫学 博士后
2020 -2023 首都医科大学 神经生物学 博士
2015-2018 河南大学 免疫学 硕士
研究概述
目前专注于利用生物信息学和深度学习模型，探索复杂脑部疾病的发病机制，以及药物治疗反应和协同效应的预测。结合免疫学和神经生物学的知识，在疾病的分子和细胞层面探寻新的生物标记和潜在的治疗靶点。通过生物信息学工具和大数据分析，从大量的基因组数据和脑部影像中提取有价值的信息，探索疾病的基本生物学机制和发病过程。
代表成果
1) Gaizhi Zhu, et al. Chickenpox and multiple sclerosis: A Mendelian randomization study. J Med Virol. 2023 Jan;95(1):e28315. doi: 10.1002/jmv.28315
2) Gaizhi Zhu#, Shan Zhou#, et al. Mendelian randomization study on the causal effects of COVID-19 on childhood intelligence. J Med Virol. 2022 Jul;94(7):3233-3239.
3) Gaizhi Zhu#, Shan Zhou#, et al. Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis. Clin Rheumatol. 2022 May;41(5):1305-1312.
4) Gaizhi Zhu#, Xiaoqian Wang#, et al. Both Notch1 and its ligands in B cells promote antibody production. Mol Immunol. 2017 Nov; 91:17-23.
5) Gaizhi Zhu#, Xiaoling Liu#, et al. Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells. Cell Immunol. 2018 Jun; 328:9-17.
6) Shan Zhou#, Gaizhi Zhu#, et al. Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain. Front Nutr. 2022 Feb 14; 9:819-635.
7) Yu Zhang#, Gaizhi Zhu#, et al. CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells. J Cell Mol Med. 2017 Dec; 21(12):3658-3669.
8) Youdi He#, Ying Fang#, Bing Zhai#, Xiaoling Liu#, Gaizhi Zhu#, et al. Gm40600 promotes CD4+ T-cell responses by interacting with Ahnak. Immunology. 2021 Sep;164(1):190-206.
9) Chen Xing#, Gaizhi Zhu#, et al. B cells regulate thymic CD8+T cell differentiation in lupus-prone mice. Oncotarget. 2017 Jul 5;8(52):89486-89499.
10) LI H, ZHU G Z, et al. Establishment of long-term potentiation method in hippocampal slices from aged mice[J]. Experimental Technology and Management, 2021, 38(8): 51-54. (In Chinese)
