教育经历
2007.9-2014.7 中国医科大学七年制英文班 临床医学学士/神经病学专业硕士学位 (Chinese Medical University, Seven-year System in English, Bachelor of Clinical Medicine / Master of Neurology) 2014.9-2018.7 首都医科大学宣武医院 神经病学专业博士学位 (Capital Medical University, Xuanwu Hospital, Doctor of Neurology) 2015.9-2017.9 哈佛医学院附属麻省总医院神经生物学实验室 联合培养 (Harvard Medical School, Affiliated Massachusetts General Hospital, Laboratory of Neuroscience, Cooperation)
工作经历
2019.12-至今 北京脑重大疾病研究院低氧适应医学研究平台 讲师 2020.9-2021.9 首都医科大学宣武医院 神经内科住院医师规范化培训一阶段 (Capital Medical University, Xuanwu Hospital, First Stage of Residency in Neurology) 2021.9-至今 首都医科大学宣武医院 神经内科住院医师规范化培训二阶段 (Capital Medical University, Xuanwu Hospital, Second Stage of Residency in Neurology)
研究概述
缺血性卒中发生率、致死率和致残率非常高，目前动物实验证明有效的神经保护剂在临床实验中均未得到阳性结果，无法转化为临床治疗是目前卒中临床和科研的瓶颈之一。兰晶博士发现神经保护剂对正常血压大鼠和高血压大鼠的卒中保护作用不同，同时参与发现昼夜节律可以影响神经保护剂对卒中的作用。为神经保护剂临床转化实验提供新思路，同时为卒中临床治疗做出一定贡献。
Ischemic stroke has a high rate of incidence, mortality and disability. Neuroprotective agents that have been proved effective in animal experiments are all failed in clinical trials, which is a bottleneck in clinical treatment and scientific research of stroke. Dr. Lan found that neuroprotective agents have different effects on normotensive stroke and hypertensive stroke, and participated in finding that circadian rhythm can affect the effect of neuroprotective agents on stroke. This provided a new idea for clinical translation of neuroprotective agents and made some contributions to clinical treatment of stroke.
代表成果
发表文章 1. Jing Lan, Elga Esposito, Cenk Ayata, Aneesh B Singhal, Eng H Lo, Xunming Ji. Different Effects of Normobaric Oxygen in Normotensive versus Hypertensive Rats after Focal Cerebral Ischemia. Stroke. 2018 Jun;49(6):1534-1537. 2. Jing Lan, Shuzhen Guo, Jingfei Shi, Elga Esposito, Emiri T Mandeville, Wenjun Deng, Christiane D Wrann, MingMing Ning, Xunming Ji, Eng H Lo. Effects of hypertension and exercise in the brain and heart vasculome of rats. Conditioning Medicine. 2019, 2(1): 63-74. 3. Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji and Eng H Lo. Cell Mechanisms and Clinical Targets in Stroke.2018 Feb; 25-34. World Scientific Publishing Co; ISBN 978-981-4723-29-9. 4. Elga Esposito, Wenlu Li, Emiri T Mandeville, Ji-Hyun Park, Ikbal Şencan, Shuzhen Guo, Jingfei Shi, Jing Lan, Janice Lee, Kazuhide Hayakawa, Sava Sakadžić, Xunming Ji, Eng H Lo. Potential circadian effects on translational failure for neuroprotection. Nature. 2020 Jun;582(7812):395-398. 5. Zhanyang Yu, Wenlu Li, Jing Lan, Kazuhide Hayakawa, Xunming Ji, Eng H Lo, Xiaoying Wang. EphrinB2-EphB2 signaling for dendrite protection after neuronal ischemia in vivo and oxygen-glucose deprivation in vitro. Journal of Cerebral Blood Flow & Metabolism. 2021 Jul;41(7):1744-1755. 6. Sherry H-Y Chou, Jing Lan, Elga Esposito, MingMing Ning, Leonora Balaj, Xunming Ji, Eng H Lo, Kazuhide Hayakawa. Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage. Stroke. 2017 Aug;48(8):2231-2237. 7. 兰晶，曹云鹏。症状性大脑中动脉狭窄程度与卒中再发的Meta分析。中风与神经疾病杂志, 2014,(4):342-344. 8. 兰晶，曹云鹏。大脑中动脉狭窄的治疗和预后。国际脑血管病杂志, 2014,(1):57-61.
